Fading SARS-CoV-2 humoral VOC cross-reactivity and sustained cellular immunity in convalescent children and adolescents

  • Cross-reactive cellular and humoral immunity can substantially contribute to antiviral defense against SARS-CoV-2 variants of concern (VOC). While the adult SARS-CoV-2 cellular and humoral immunity and its cross-recognition potential against VOC is broadly analyzed, similar data regarding the pediatric population are missing. In this study, we perform an analysis of the humoral and cellular SARS-CoV-2 response immune of 32 convalescent COVID-19 children (children), 27 convalescent vaccinated adults(C + V+) and 7 unvaccinated convalescent adults (C + V-). Similarly to adults, a significant reduction of cross-reactive neutralizing capacity against delta and omicron VOC was observed 6 months after SARS-CoV-2 infection. While SAR-CoV-2 neutralizing capacity was comparable among children and C + V- against all VOC, children demonstrated as expected an inferior humoral response when compared to C + V+. Nevertheless, children generated SARS-CoV-2 reactive T cells with broad cross-recognition potential. When compared to V + C+, children presented even comparable frequencies of WT-reactive CD4 + and CD8 + T cells with high avidity and functionality. Taking into consideration the limitations of study - unknown disease onset for 53% of the asymptomatic pediatric subjects, serological detection of SARS-CoV-2 infection-, our results suggest that following SARS-CoV-2 infection children generate a humoral SARS-CoV-2 response with neutralizing potential comparable to unvaccinated COVID-19 convalescent adults as well a sustained SARS-CoV-2 cellular response cross-reactive to VOC.

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Author:Krystallenia PaniskakiORCiDGND, Sarah GoretzkiGND, Moritz AnftGND, Margarethe KonikGND, Klara LechtenbergGND, Melanie VoglGND, Toni Luise MeisterORCiDGND, Stephanie PfänderORCiDGND, Markus ZettlerGND, Jasmin JägerGND, Sebastian DolffORCiDGND, Timm WesthoffORCiDGND, Hana RohnGND, Ursula Felderhoff-MüserGND, Ulrik Stervbo-KristensenORCiDGND, Oliver WitzkeGND, Christian Dohna-SchwakeORCiDGND, Nina BabelORCiDGND
Parent Title (English):BMC Infectious diseases
Publisher:BioMed Central, Part of Springer Nature
Place of publication:London
Document Type:Article
Date of Publication (online):2024/04/15
Date of first Publication:2023/11/22
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Tag:Open Access Fonds
Adaptive immunity; Children; Neutralizing antibodies; T cells
Issue:Artikel 818
First Page:818-1
Last Page:818-12
Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum.
Institutes/Facilities:Marienhospital Herne, Centrum für Translationale Medizin mit Schwerpunkt Immunologie und Transplantation
Dewey Decimal Classification:Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit
open_access (DINI-Set):open_access
Licence (English):License LogoCreative Commons - CC BY 4.0 - Attribution 4.0 International