Body composition predictors of complicated Crohn’s disease

  • \(\bf Background:\) High visceral adipose tissue (VAT) and creeping fat (CrF) in Crohn’s disease (CD) have been widely recognized. The VAT to subcutaneous adipose tissue (SAT) ratio and sarcopenia have been associated with CD complications. Studies regarding the influence of body composition predictors on CD complications assessed with magnetic resonance enterography (MRE) are scarce. \(\bf Aim:\) The aim of this study was to assess body composition parameters and CrF in opportunistic MRE as predictors of complicated CD. \(\bf Methods:\) This was a retrospective study of 114 patients with inflammatory (\(\it n\) = 54) and complicated ((\(\it n\) = 60) CD. The semiautomated assessment of body composition and the qualitative evaluation of CrF were performed. \(\bf Results:\) Body composition parameters did not differ between both groups regarding the body mass index ((\(\it p\) = 0.50), total adipose tissue index (TATI) ((\(\it p\) = 0.14), subcutaneous adipose tissue index (SATI) ((\(\it p\) = 0.17), visceral adipose tissue index (VATI) ((\(\it p\) = 0.33), VAT/SAT ratio ((\(\it p\) = 0.77), intramuscular adipose tissue ((\(\it p\) = 0.64), skeletal muscle index ((\(\it p\) = 0.22), and sarcopenia ((\(\it p\) = 0.50). 47 strictures, 18 fistulae, and seven abscesses were identified. Fistulae were more likely to occur in patients with CrF (odds ratio [OR] 5.07, 95% confidence interval [CI] 1.76–14.56; p=<0.001) and high VAT/SAT ratio (OR: 3.82, 95% CI 1.34–10.85; (\(\it p\) = 0.01). \(\bf Conclusion:\) Body composition measurements in CD patients displayed no statistically significant difference between the groups of inflammatory and complicated disease. Nonetheless, CD patients stratified in the group of high VAT/SAT ratio and the presence of CrF should be recognized as risk groups for the occurrence of fistulae.

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Author:Felix Barajas OrdonezORCiDGND, Bohdan MelekhGND, Pablo Rodríguez-FeriaORCiDGND, Oksana MelekhGND, Maximilian ThormannGND, Robert DammORCiDGND, Jazan OmariGND, Maciej PechORCiDGND, Alexey SurovORCiDGND
Parent Title (English):Digestive diseases
Place of publication:Basel
Document Type:Article
Date of Publication (online):2024/04/19
Date of first Publication:2023/01/31
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Tag:Crohn’s disease; Fistula; Sarcopenia; Subcutaneous adipose tissue; Visceral adipose tissue
First Page:589
Last Page:599
Institutes/Facilities:Johannes Wesling Klinikum Minden, Institut für Diagnostische Radiologie, Neuroradiologie und Nuklearmedizin
Dewey Decimal Classification:Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit
open_access (DINI-Set):open_access
Licence (English):License LogoCreative Commons - CC BY 4.0 - Attribution 4.0 International