Wie RNA-Thermometer die Sekretion von Virulenzfaktoren kontrollieren

  • Pathogenic bacteria use outer membrane vesicles (OMVs) and highly adapted machineries like the type 3 secretion system (T3SS) to deliver virulence factors into host cells. The secretion of such effector proteins is tightly regulated. In the foodborne human pathogen \(\textit {Yersinia pseudotuberculosis}\), several thermo-responsive RNA elements, termed RNA thermometers, are strategically positioned at critical checkpoints of virulence regulation. They use a temperature-dependent, zipper-like mechanism to control translation initiation of genes for several T3SS components and an exotoxin.

Download full text files

Export metadata

Additional Services

Share in Twitter Search Google Scholar
Author:Soheila JavadiGND, Stephan PienkoßGND, Franz NarberhausORCiDGND
Parent Title (German):Biospektrum
Place of publication:Heidelberg
Document Type:Article
Date of Publication (online):2024/04/22
Date of first Publication:2024/02/15
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
First Page:9
Last Page:11
Dieser Beitrag ist auf Grund des DEAL-Springer-Vertrages frei zugänglich.
Institutes/Facilities:Lehrstuhl für Biologie der Mikroorganismen
Dewey Decimal Classification:Naturwissenschaften und Mathematik / Biowissenschaften, Biologie, Biochemie
open_access (DINI-Set):open_access
faculties:Fakultät für Biologie und Biotechnologie
Licence (German):License LogoCreative Commons - CC BY 4.0 - Namensnennung 4.0 International