Wie RNA-Thermometer die Sekretion von Virulenzfaktoren kontrollieren
- Pathogenic bacteria use outer membrane vesicles (OMVs) and highly adapted machineries like the type 3 secretion system (T3SS) to deliver virulence factors into host cells. The secretion of such effector proteins is tightly regulated. In the foodborne human pathogen \(\textit {Yersinia pseudotuberculosis}\), several thermo-responsive RNA elements, termed RNA thermometers, are strategically positioned at critical checkpoints of virulence regulation. They use a temperature-dependent, zipper-like mechanism to control translation initiation of genes for several T3SS components and an exotoxin.
| Author: | Soheila JavadiGND, Stephan PienkoßGND, Franz NarberhausORCiDGND |
|---|---|
| URN: | urn:nbn:de:hbz:294-111256 |
| DOI: | https://doi.org/10.1007/s12268-024-2091-3 |
| Parent Title (German): | Biospektrum |
| Publisher: | Springer |
| Place of publication: | Heidelberg |
| Document Type: | Article |
| Language: | German |
| Date of Publication (online): | 2024/04/22 |
| Date of first Publication: | 2024/02/15 |
| Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
| Volume: | 30 |
| First Page: | 9 |
| Last Page: | 11 |
| Note: | Dieser Beitrag ist auf Grund des DEAL-Springer-Vertrages frei zugänglich. |
| Institutes/Facilities: | Lehrstuhl für Biologie der Mikroorganismen |
| Dewey Decimal Classification: | Naturwissenschaften und Mathematik / Biowissenschaften, Biologie, Biochemie |
| open_access (DINI-Set): | open_access |
| faculties: | Fakultät für Biologie und Biotechnologie |
| Licence (German): |  Creative Commons - CC BY 4.0 - Namensnennung 4.0 International |
