Stress-mediated abnormalities in regional myocardial wall motion in young women with a history of psychological trauma

  • \(\bf Background:\) Psychosocial stress has been associated with the development and progression of atherosclerotic cardiovascular disease (CVD). Previously, we reported subtle differences in global longitudinal strain in somatically healthy women with a psychiatric diagnosis of borderline personality disorder (BPD). This study aimed to investigate the impact of BPD on segmental myocardial wall motion using speckle tracking echocardiography (STE) analysis. \(\bf Methods:\) A total of 100 women aged between 18 and 38 years were included in this study. Fifty patients meeting the diagnostic criteria for BPD were recruited from the Department of Psychiatry (LWL-University Hospital Bochum) and compared with fifty age-matched healthy control subjects without previous cardiac disease. Laboratory tests and STE were performed with segmental wall motion analysis. \(\bf Results:\) The BPD group had a higher prevalence of risk factors for CVD, with smoking and obesity being predominant, when compared with the control group. Other cardiovascular parameters such as blood pressure, glucose, and cholesterol levels were also elevated, even though not to pathological values. Moreover, in the STE analysis, the BPD group consistently exhibited decreased deformation in nine myocardial wall regions compared with the control group, along with a shift toward higher values in the distribution of peak pathological segments. Additionally, significantly higher values of free thyroxine concentration and thyroid’s secretory capacity were observed in the BPD group, despite falling within the (high-) normal range. \(\bf Conclusions:\) BPD is associated with chronic stress, classical risk factors, and myocardial wall motion abnormalities. Further exploration is warranted to investigate the relationship between high-normal thyroid metabolism, these risk factors, and myocardial function in BPD patients. Long-term follow-up studies would be valuable in confirming the potential for predicting adverse events.

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Author:Assem AweimerORCiDGND, Luisa EngemannGND, Sameh AmarGND, Aydan EwersGND, Faegheh AfshariGND, Clara Marie MaißGND, Lisa Katharina KernGND, Thomas LückeGND, Andreas MüggeORCiDGND, Ibrahim El-BattrawyORCiDGND, Johannes Wolfgang Christian DietrichORCiDGND, Martin BrüneORCiDGND
Parent Title (English):Journal of clinical medicine
Place of publication:Lausanne
Document Type:Article
Date of Publication (online):2024/03/21
Date of first Publication:2023/10/24
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Tag:Open Access Fonds
psychological trauma; regional wall motion; risk factors; speckle tracking echocardiography; stress cardiomyopathy
Issue:21, Artikel 6702
First Page:6702-1
Last Page:6702-11
Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum.
Institutes/Facilities:Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Medizinische Klinik II, Kardiologie und Angiologie
Dewey Decimal Classification:Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit
open_access (DINI-Set):open_access
Licence (English):License LogoCreative Commons - CC BY 4.0 - Attribution 4.0 International