Chicken embryo as a model in second heart field development

  • Previously, a single source of \(\underline {progenitor}\) \(\underline {cells}\) was thought to be responsible for the formation of the \(\underline {cardiac}\) \(\underline {muscle}\). However, the second heart field has recently been identified as an additional source of myocardial p\(\underline {progenitor}\) \(\underline {cells}\). The chicken embryo, which develops in the egg, outside the mother can easily be manipulated \(\textit {in vivo}\) and \(\textit {in vitro}\). Hence, it was an excellent model for establishing the concept of the second heart field. Here, our review will focus on the chicken model, specifically its role in understanding the second heart field. In addition to discussing historical aspects, we provide an overview of recent findings that have helped to define the chicken second heart field \(\underline {progenitor}\) \(\underline {cells}\). A better understanding of the second heart field development will provide important insights into the \(\underline {congenital}\) \(\underline {malformations}\) affecting \(\underline {cardiac}\) \(\underline {muscle}\) formation and function.

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Author:Imadeldin YahyaORCiDGND, Beate Brand-SaberiORCiDGND, Gabriela Morosan-PuopoloORCiDGND
Parent Title (English):Heliyon
Publisher:Elsevier B.V.
Place of publication:Amsterdam
Document Type:Article
Date of Publication (online):2024/03/20
Date of first Publication:2023/03/03
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Tag:Open Access Fonds
Chicken embryo; First heart field; Heart; Second heart field
Issue:3, Artikel e14230
First Page:e14230-1
Last Page:e14230-11
Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum.
Institutes/Facilities:Institut für Anatomie, Abteilung für Anatomie und Molekulare Embryologie
Dewey Decimal Classification:Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit
open_access (DINI-Set):open_access
faculties:Fakultät für Biologie und Biotechnologie
Licence (English):License LogoCreative Commons - CC BY-NC-ND 4.0 - Attribution-NonCommercial-NoDerivatives 4.0 International