Tasks and experiences of the prospective, longitudinal, multicenter MoMar (Molecular Markers) study for the early detection of mesothelioma in individuals formerly exposed to asbestos using liquid biopsies

  • Mesothelioma is an aggressive cancer, strongly associated with prior exposure to asbestos. Commonly, tumors are detected at late stages of the disease. Detection at early stages might be meaningful, because therapies might be more effective when the tumor burden is relatively low and the tumor has not spread to distant sites. Circulating biomarkers in blood might be a promising tool to improve the early detection of mesothelioma, but for screening in asymptomatic subjects, candidate biomarkers need to be validated in appropriate studies. This study was conducted to assess the performance of biomarkers in liquid biopsies to detect mesothelioma at early stages. Over a period of 10 years, 2769 volunteers formerly exposed to asbestos were annually examined and liquid biopsies were collected. A follow-up was completed 17 months after the last blood collection. The article provides a detailed overview of our lessons learned and experiences of conducting a prospective, longitudinal, multicenter study. The existing cohort of individuals at risk is highly suitable for the validation of blood-based biomarkers for the early detection of mesothelioma as well as lung cancer.

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Author:Daniel G. WeberORCiDGND, Swaantje CasjensORCiDGND, Katharina WichertGND, Martin LehnertGND, Dirk TaegerORCiDGND, Hans-Peter RihsORCiDGND, Thomas BrüningORCiDGND, Georg JohnenORCiDGND
Parent Title (English):Cancers
Place of publication:Basel
Document Type:Article
Date of Publication (online):2024/03/19
Date of first Publication:2023/12/18
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Tag:Open Access Fonds
Calretinin; asbestos; blood-based; cancer; cohort; liquid biopsies; lung cancer; mesothelin; mesothelioma
Issue:24, Artikel 5896
First Page:5896-1
Last Page:5896-17
Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum.
Institutes/Facilities:Institut für Prävention und Arbeitsmedizin der Deutschen Gesetzlichen Unfallversicherung
Dewey Decimal Classification:Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit
open_access (DINI-Set):open_access
Licence (English):License LogoCreative Commons - CC BY 4.0 - Attribution 4.0 International