Primary thyroid dysfunction is prevalent in hidradenitis suppurativa and marked by a signature of Hhypothyroid graves’ disease

  • Hidradenitis suppurativa (HS) is a chronic skin disease that can have an association with endocrine disorders. There is conflicting information in the literature regarding the role of the thyroid gland in HS. This study aimed to close this knowledge gap and investigate how thyroid disease is involved in patients with HS. We carried out a case–control study with a total of 160 patients, of whom 108 were patients with HS and 52 were controls matched for age and sex. Parametric and non-parametric methods were used to analyze the results. We calculated structural parameters of thyroid homeostasis to detect subclinical thyroid disease, non-thyroid disease syndrome and other forms. The severity of HS was not associated with thyroid hormone levels and antibodies (\(\it p\) > 0.05). HS patients with or without hypothyroidism had decreased FT4 levels and a decreased thyroid secretory capacity (SPINA-GT). Titers of TSH receptor autoantibodies (TRAb) were significantly higher in smoking HS patients compared to non-smokers (median: 1.18 vs. 1.08; \(\it p\) = 0.042). The rate of subclinical hypothyroidism was significantly higher in HS patients; thus, subclinical hypothyroidism is an important comorbidity of HS (\(\it p\) < 0.05). Further studies are needed to investigate whether the chronic inflammation of HS is a cause of increased rates of (subclinical) hypothyroidism.

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Author:Nessr Abu RachedORCiDGND, Johannes Wolfgang Christian DietrichORCiDGND, Lennart OckerGND, Daniel Robert QuastORCiDGND, Christina ScheelORCiDGND, Thilo GambichlerORCiDGND, Falk Georges BecharaORCiDGND
Parent Title (English):Journal of clinical medicine
Subtitle (English):A case–control study
Place of publication:Basel
Document Type:Article
Date of Publication (online):2024/03/11
Date of first Publication:2023/12/04
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Tag:Open Access Fonds
HS; SPINA-GD; SPINA-GT; acne inversa; autoimmunity; hormones; obesity; thyroid function; thyroxine; triiodothyronine
GND-Keyword:Hidradenitis Suppurativa
Issue:23, Artikel 7490
First Page:7490-1
Last Page:7490-14
Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum.
Institutes/Facilities:Katholisches Klinikum Bochum, Hauttumorzentrum
Katholisches Klinikum Bochum, Dermatologie, Venerologie und Allergologie
Dewey Decimal Classification:Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit
open_access (DINI-Set):open_access
Licence (English):License LogoCreative Commons - CC BY 4.0 - Attribution 4.0 International