Towards a physiologically accurate ECG from numerical simulations

  • Numerical simulations of the human heart can guide medical doctors and researchers only if properly validated. This work presents a computational framework to validate mathematical models of cardiac electrophysiology at the tissue level. Specifically, we focus on the transmural wedge experiment as proposed by Antzelevitch in 1996. This experimental setup is easily reproduced and allows to probe key modeling assumptions and components before organ level simulations are performed. Our results highlight the need to further investigate the conductivity tensor, which, by modifying wave propagation, will affect the ECG morphology at the organ level.

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Author:Dennis OgiermannORCiDGND, Luigi E. PerottiORCiDGND, Daniel BalzaniORCiDGND
Parent Title (English):Proceedings in applied mathematics & mechanics
Subtitle (English):comparative analyses in a simplified tissue model
Place of publication:Weinheim
Document Type:Article
Date of Publication (online):2024/03/08
Date of first Publication:2021/01/25
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Issue:1, Artikel e202000136
First Page:e202000136-1
Last Page:e202000136-3
Dieser Beitrag ist auf Grund des DEAL-Wiley-Vertrages frei zugänglich.
Institutes/Facilities:Lehrstuhl für Mechanik - Kontinuumsmechanik
Dewey Decimal Classification:Technik, Medizin, angewandte Wissenschaften / Ingenieurbau, Umwelttechnik
open_access (DINI-Set):open_access
faculties:Fakultät für Bau- und Umweltingenieurwissenschaften
Licence (English):License LogoCreative Commons - CC BY 4.0 - Attribution 4.0 International