Towards a physiologically accurate ECG from numerical simulations
- Numerical simulations of the human heart can guide medical doctors and researchers only if properly validated. This work presents a computational framework to validate mathematical models of cardiac electrophysiology at the tissue level. Specifically, we focus on the transmural wedge experiment as proposed by Antzelevitch in 1996. This experimental setup is easily reproduced and allows to probe key modeling assumptions and components before organ level simulations are performed. Our results highlight the need to further investigate the conductivity tensor, which, by modifying wave propagation, will affect the ECG morphology at the organ level.
| Author: | Dennis OgiermannORCiDGND, Luigi E. PerottiORCiDGND, Daniel BalzaniORCiDGND |
|---|---|
| URN: | urn:nbn:de:hbz:294-110241 |
| DOI: | https://doi.org/10.1002/pamm.202000136 |
| Parent Title (English): | Proceedings in applied mathematics & mechanics |
| Subtitle (English): | comparative analyses in a simplified tissue model |
| Publisher: | Wiley |
| Place of publication: | Weinheim |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2024/03/08 |
| Date of first Publication: | 2021/01/25 |
| Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
| Volume: | 20 |
| Issue: | 1, Artikel e202000136 |
| First Page: | e202000136-1 |
| Last Page: | e202000136-3 |
| Note: | Dieser Beitrag ist auf Grund des DEAL-Wiley-Vertrages frei zugänglich. |
| Institutes/Facilities: | Lehrstuhl für Mechanik - Kontinuumsmechanik |
| Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Ingenieurbau, Umwelttechnik |
| open_access (DINI-Set): | open_access |
| faculties: | Fakultät für Bau- und Umweltingenieurwissenschaften |
| Licence (English): |  Creative Commons - CC BY 4.0 - Attribution 4.0 International |
