Computational analysis of the influence of drusen growth on the morphology of RPE due to Age-related Macular Degeneration

  • Age-related macular degeneration (AMD) is a disease that affects the macular region of the outer retina. AMD is characterized by the presence of large extracellular debris called drusen between the Bruch's Membrane (BrM) in the choroid and the retinal pigment epithelium (RPE) in the outer retina. An important feature of AMD is the degenerative changes in the RPE and the photoreceptors that leads to the deterioration and loss of central vision. In this contribution, the effect of drusen size on the morphological changes in the RPE, BrM and photoreceptors are investigated using the cellular potts model (CPM) and machine learning. Numerical simulation of the influence of drusen growth and its effect on the morphology of the outer retinal layers of the macula is presented and the implications for AMD progression discussed.

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Author:Vijaya HollaORCiDGND, Jithender J. TimothyORCiDGND, Günther MeschkeORCiDGND
Parent Title (English):Proceedings in applied mathematics & mechanics
Place of publication:Weinheim
Document Type:Article
Date of Publication (online):2024/03/08
Date of first Publication:2021/01/25
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Issue:1, Artikel e202000298
First Page:e202000298-1
Last Page:e202000298-3
Dieser Beitrag ist auf Grund des DEAL-Wiley-Vertrages frei zugänglich.
Institutes/Facilities:Lehrstuhl für Statik und Dynamik
Dewey Decimal Classification:Technik, Medizin, angewandte Wissenschaften / Ingenieurbau, Umwelttechnik
open_access (DINI-Set):open_access
faculties:Fakultät für Bau- und Umweltingenieurwissenschaften
Licence (English):License LogoCreative Commons - CC BY 4.0 - Attribution 4.0 International