Cold plasma therapy in chronic wounds — a multicenter, randomized controlled clinical trial (Plasma on Chronic Wounds for Epidermal Regeneration Study)

  • Chronic wounds (CWs) pose a significant health challenge in clinical practice. Standard wound therapy (SWT) is currently considered the gold standard. However, recent evidence suggests that cold plasma therapy (CPT) holds promise for improving CWs. In light of this, the POWER study was conducted as a multicenter, randomized clinical trial to investigate the effect of large-area plasma application compared with SWT in patients with chronic, non-healing arterial or venous wounds on the lower leg. To analyze the interim results, we employed a comprehensive range of statistical tests, including both parametric and non-parametric methods, as well as GLS model regression and an ordinal mixed model. Our findings clearly demonstrate that CPT therapy significantly accelerates wound closure compared with SWT. In fact, complete wound closure was exclusively observed in the CPT group during the intervention period. Additionally, the CPT group required significantly less antibiotic therapy (4%) compared with the SWT group (23%). Furthermore, CPT led to a significant reduction in wound pain and improved quality of life compared with SWT. In conclusion, the study highlights that the combination of CPT and SWT surpasses monotherapy with SWT alone.

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Author:Nessr Abu RachedORCiDGND, Susanne KleyGND, Martin StorckGND, Thomas MeyerORCiDGND, Markus StückerGND
Parent Title (English):Journal of clinical medicine
Subtitle (English):Preliminary results
Place of publication:Basel
Document Type:Article
Date of Publication (online):2024/03/04
Date of first Publication:2023/08/04
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Tag:chronic wounds; cold plasma; epidermal regeneration; health economics; plasma; plasma therapy; wound; wound-healing disorder
GND-Keyword:Diabetes mellitus; Open Access Fonds
Issue:15, Artikel 5121
First Page:5121-1
Last Page:5121-17
Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum.
Institutes/Facilities:Katholisches Klinikum Bochum, Dermatologie, Venerologie und Allergologie
Dewey Decimal Classification:Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit
open_access (DINI-Set):open_access
Licence (English):License LogoCreative Commons - CC BY 4.0 - Attribution 4.0 International