Matthias Krumb, Maximilian Jäger, Alice Voss, Loreen Immig, Karin Peters, Danuta Kowalczyk, Albrecht Bufe, Till Opatz, Otto Holst, Christian Vogel, Marcus Peters
- Arabinogalactan, a microheterogeneous polysaccharide occurring in plants, is known for its allergy-protective activity, which could potentially be used for preventive allergy treatment. New treatment options are highly desirable, especially in a preventive manner, due to the constant rise of atopic diseases worldwide. The structural origin of the allergy-protective activity of arabinogalactan is, however, still unclear and isolation of the polysaccharide is not feasible for pharmaceutical applications due to a variation of the activity of the natural product and contaminations with endotoxins. Therefore, a pentasaccharide partial structure was selected for total synthesis and subsequently coupled to a carrier protein to form a neoglycoconjugate. The allergy-protective activity of arabinogalactan could be reproduced with the partial structure in subsequent in vivo experiments. This is the first example of a successful simplification of arabinogalactan with a single partial structure while retaining its allergy-preventive potential.
Metadaten| Author: | Matthias KrumbORCiDGND, Maximilian JägerGND, Alice VossGND, Loreen ImmigGND, Karin PetersGND, Danuta KowalczykGND, Albrecht BufeORCiDGND, Till OpatzORCiDGND, Otto HolstORCiDGND, Christian VogelGND, Marcus PetersORCiDGND |
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| URN: | urn:nbn:de:hbz:294-109511 |
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| DOI: | https://doi.org/10.1002/chem.202002287 |
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| Parent Title (English): | Chemistry - a European journal |
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| Publisher: | Wiley |
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| Place of publication: | Hoboken, New Jersey |
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| Document Type: | Article |
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| Language: | English |
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| Date of Publication (online): | 2024/02/29 |
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| Date of first Publication: | 2020/06/24 |
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| Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
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| Tag: | airway inflammation; allergy protection; arabinogalactan; carbohydrates; total synthesis |
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| Volume: | 27 |
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| Issue: | 3 |
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| First Page: | 928 |
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| Last Page: | 933 |
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| Note: | Dieser Beitrag ist auf Grund des DEAL-Wiley-Vertrages frei zugänglich. |
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| Institutes/Facilities: | Medizinische Fakultät, Abteilung für Molekulare Immunologie |
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| Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
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| open_access (DINI-Set): | open_access |
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| faculties: | Medizinische Fakultät |
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| Licence (English): |  Creative Commons - CC BY-NC-ND 4.0 - Attribution-NonCommercial-NoDerivatives 4.0 International |
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