Total synthesis of a partial structure from arabinogalactan and its application for allergy prevention

  • Arabinogalactan, a microheterogeneous polysaccharide occurring in plants, is known for its allergy-protective activity, which could potentially be used for preventive allergy treatment. New treatment options are highly desirable, especially in a preventive manner, due to the constant rise of atopic diseases worldwide. The structural origin of the allergy-protective activity of arabinogalactan is, however, still unclear and isolation of the polysaccharide is not feasible for pharmaceutical applications due to a variation of the activity of the natural product and contaminations with endotoxins. Therefore, a pentasaccharide partial structure was selected for total synthesis and subsequently coupled to a carrier protein to form a neoglycoconjugate. The allergy-protective activity of arabinogalactan could be reproduced with the partial structure in subsequent in vivo experiments. This is the first example of a successful simplification of arabinogalactan with a single partial structure while retaining its allergy-preventive potential.

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Author:Matthias KrumbORCiDGND, Maximilian JägerGND, Alice VossGND, Loreen ImmigGND, Karin PetersGND, Danuta KowalczykGND, Albrecht BufeORCiDGND, Till OpatzORCiDGND, Otto HolstORCiDGND, Christian VogelGND, Marcus PetersORCiDGND
Parent Title (English):Chemistry - a European journal
Place of publication:Hoboken, New Jersey
Document Type:Article
Date of Publication (online):2024/02/29
Date of first Publication:2020/06/24
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Tag:airway inflammation; allergy protection; arabinogalactan; carbohydrates; total synthesis
First Page:928
Last Page:933
Dieser Beitrag ist auf Grund des DEAL-Wiley-Vertrages frei zugänglich.
Institutes/Facilities:Medizinische Fakultät, Abteilung für Molekulare Immunologie
Dewey Decimal Classification:Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit
open_access (DINI-Set):open_access
faculties:Medizinische Fakultät
Licence (English):License LogoCreative Commons - CC BY-NC-ND 4.0 - Attribution-NonCommercial-NoDerivatives 4.0 International