Assessment of pulmonary artery stiffness by multiparametric cardiac magnetic resonance-surrogate for right heart catheterization

  • \(\bf Background:\) Cardiac magnetic resonance (CMR) imaging allows for multiparametric assessment of healthy pulmonary artery (PA) hemodynamics. Gender- and aging-associated PA stiffness and pressure alterations have remained clinically unestablished, however may demonstrate epidemiological differences in disease development. The aim of this study is to evaluate the role of CMR as a surrogate for catheter examinations by providing a comprehensive CMR assessment of sex- and age-related reference values for PA stiffness, flow, and pressure. \(\textbf {Methods and Results:}\) PA hemodynamics were studied between gender and age groups (>/<50 years) using phase-contrast CMR. Corresponding correlation analyses were performed. 179 healthy volunteers with a median age of 32.6 years (range 11.3–68.2) were examined. Males demonstrated increased PA compliance (median [interquartile range] or mean \(\pm\) standard deviation) (20.8 \(mm^{2}\)/mmHg [16.6; 25.8] vs. 19.2 \(\pm\) 7.1 \(mm^{2}\)/mmHg; \(\it P\) < 0.033), higher pulse wave velocity (2.00 m/s [1.35; 2.87] vs. 1.73 m/s [1.19; 2.34]; \(\it P\) = 0.018) and a reduced full width half maximum (FWHM) (219 \(\pm\) 22 ms vs. 235 \(\pm\) 23 ms; \(\it P\) < 0.001) than females. Mean, systolic, diastolic PA pressure and pulmonary proportional pulse pressure were significantly elevated for males compared to females (\(\it P\) < 0.001). Older subjects (>50 years) exhibited reduced PA elasticity (41.7% [31.0; 52.9] vs. 66.4% [47.7; 83.0]; \(\it P\) < 0.001), reduced PA compliance (15.4 \(mm^{2}\)/mmHg [12.3; 20.7] vs. 21.3 \(\pm\) 6.8 \(mm^{2}\)/mmHg; \(\it P\) < 0.001), higher pulse wave velocity (2.59 m/s [1.57; 3.59] vs. 1.76 m/s [1.24; 2.34]; \(\it P\) < 0.001) and a reduced FWHM (218 \(\pm\) 29 ms vs. 231 \(\pm\) 21 ms; \(\it P\) < 0.001) than younger subjects. \(\bf Conclusions:\) Velocity-time profiles are dependent on age and gender. PA stiffness indices deteriorate with age. CMR has potential to serve as a surrogate for right heart catheterization.

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Author:Hermann KörperichORCiDGND, Jan Wigand EcksteinORCiDGND, Medhat AtitoGND, Peter BarthGND, Kai Thorsten LaserORCiDGND, Wolfgang BurchertORCiDGND, Oliver M. WeberGND, Christian StehningGND, Misagh PiranORCiDGND
Parent Title (English):Frontiers in cardiovascular medicine
Publisher:Frontiers Media
Place of publication:Lausanne
Document Type:Article
Date of Publication (online):2024/02/28
Date of first Publication:2023/08/25
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Tag:Open Access Fonds
cardiovascular magnetic resonance; hemodynamics; pulmonary artery pressure; pulmonary artery stiffness; pulse wave velocity; reference values; right heart catheterization
Issue:Article 1200833
First Page:1200833-01
Last Page:1200833-13
Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum.
Institutes/Facilities:Herz- und Diabeteszentrum NRW
Herz- und Diabeteszentrum NRW, Institut für Radiologie, Nuklearmedizin und molekulare Bildgebung
Dewey Decimal Classification:Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit
open_access (DINI-Set):open_access
Licence (English):License LogoCreative Commons - CC BY 4.0 - Attribution 4.0 International