Severity of inflammation is associated with food intake in hospitalized geriatric patients

  • The extent to which inflammation impacts food intake remains unclear, serving as a key risk factor for malnutrition as defined by the Global Leadership Initiative on Malnutrition (GLIM). To address this, we analyzed a large, merged dataset of geriatric hospitalized patients across Europe. The study included 1650 consecutive patients aged \(\geq\)65 year from Germany, Italy, Finland, Denmark, and Poland. Nutritional intake was assessed using the first item of the Mini Nutritional Assessment Short Form; C-reactive protein (CRP) levels were measured using standard procedures. In total (age 79.6 \(\pm\) 7.4 year, 1047 females), 23% exhibited moderate to severe inflammation, and 12% showed severe inflammation; 35% showed moderate reductions in food intake, and 28% were considered malnourished. Median CRP levels differed significantly between patients with severe, moderate, and no decrease in food intake. Among patients with a CRP level of 3.0–4.99 mg/dL, 19% experienced a severe decrease in food intake, while 66% experienced moderate to severe decreases. Regression analysis revealed that inflammation was the most prominent risk factor for low food intake and malnutrition, surpassing other factors such as age, gender, infection, and comorbidity. A CRP level of \(\geq\)3.0 mg/dL is associated with reduced food intake during last 3 months in two thirds of hospitalized geriatric patients and therefore indicative for a high risk of malnutrition.

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Author:Maryam PourhassanORCiDGND, Tommy CederholmGND, Lorenzo M. DoniniORCiDGND, Eleonora PoggiogalleGND, Ursula SchwabORCiDGND, Rikke Lundsgaard NielsenORCiDGND, Aino Leegaard AndersenORCiDGND, Sylwia MałgorzewiczORCiDGND, Dorothee VolkertGND, Rainer WirthORCiDGND
Parent Title (English):Nutrients
Subtitle (English):a merged data analysis
Place of publication:Basel
Document Type:Article
Date of Publication (online):2024/02/26
Date of first Publication:2023/07/08
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Tag:Open Access Fonds
C-reactive protein; GLIM criteria; food intake; inflammation; older persons
Issue:14, Article 3079
First Page:3079-1
Last Page:3079-12
Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum.
Institutes/Facilities:Marienhospital Herne, Klinik für Altersmedizin und Frührehabilitation
Dewey Decimal Classification:Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit
open_access (DINI-Set):open_access
Licence (English):License LogoCreative Commons - CC BY 4.0 - Attribution 4.0 International