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Paraskevi Mavrogiorgou-Juckel, Theresa Kristina Thomaßen, Frederike Pott, Vera Flasbeck, Holmer Steinfath, Georg Juckel

• \(\bf Background\) The experience of time, or the temporal order of external and internal events, is essential for humans. In psychiatric disorders such as depression and schizophrenia, impairment of time processing has been discussed for a long time. \(\bf Aims\) In this explorative pilot study, therefore, the subjective time feeling as well as objective time perception were determined in patients with depression and schizophrenia, along with possible neurobiological correlates. \(\bf Methods\) Depressed (\(\it n\) = 34; 32.4 \(\pm\) 9.8 years; 21 men) and schizophrenic patients ((\(\it n\) = 31; 35.1 \(\pm\) 10.7 years; 22 men) and healthy subjects ((\(\it n\) = 33; 32.8 \(\pm\) 14.3 years; 16 men) were tested using time feeling questionnaires, time perception tasks and critical flicker-fusion frequency (CFF) and loudness dependence of auditory evoked potentials (LDAEP) to determine serotonergic neurotransmission. \(\bf Results\) There were significant differences between the three groups regarding time feeling and also in time perception tasks (estimation of given time duration) and CFF (the "DOWN" condition). Regarding the LDAEP, patients with schizophrenia showed a significant negative correlation to time experience in terms of a pathologically increased serotonergic neurotransmission with disturbed time feeling. \(\bf Conclusions\) Impairment of time experience seems to play an important role in depression and schizophrenia, both subjectively and objectively, and novel neurobiological correlates have been uncovered. It is suggested, therefore, that alteration of experience of time should be increasingly included in the current psychopathological findings.