Safety, mortality, and hemodynamic impact of patients with MitraClip undergoing left ventricular assist device implantation

  • The interactions and hemodynamic impact of transcatheter percutaneous mitral valve repair (TMR) have not yet been investigated in patients undergoing left ventricular assist device (LVAD) implantation, but hemodynamic adverse effects are feared in the combination of TMR and LVAD for altered mitral valve flow. This study investigated the hemodynamic interplay in combination of TMR and LVAD in 119 patients, and propensity score match analysis revealed no difference in both perioperative mortality and 2-year follow-up survival (\(\it p\) = 0.84). Nonetheless, postoperatively mean pulmonary arterial pressure, pulmonary capillary wedge pressure, and cardiac index improved, and multivariable cox regression analysis at 2 years identified preoperative total bilirubin and temporary right ventricular mechanical circulatory support as independent risk factors for all-cause mortality but not TMR. Prior TMR has no impact on mortality or cardiovascular complications in patients with LVAD.

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Author:Henrik FoxORCiDGND, Takayuki GyotenORCiDGND, Sebastian Rojas HernandezORCiDGND, Marcus-André DeutschGND, René SchrammORCiDGND, Volker RudolphORCiDGND, Jan GummertORCiDGND, Michiel MorshuisORCiDGND
Parent Title (English):Journal of cardiovascular translational research
Place of publication:New York
Document Type:Article
Date of Publication (online):2024/01/15
Date of first Publication:2021/10/28
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Tag:CentriMag system; Heart failure; Heart transplantation; HeartMate 3; Left ventricular assist device; Left ventricular dysfunction; Mechanical circulatory support; MitraClip; Mortality; Pulmonary artery pressure; Pulmonary vascular resistance; Transpulmonary gradient
First Page:676
Last Page:686
Dieser Beitrag ist auf Grund des DEAL-Springer-Vertrages frei zugänglich.
Institutes/Facilities:Herz- und Diabeteszentrum NRW
Herz- und Diabeteszentrum NRW, Klinik für Thorax- und Kardiovaskularchirurgie
Herz- und Diabeteszentrum NRW, Zentrum für Herzinsuffizienz
Dewey Decimal Classification:Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit
open_access (DINI-Set):open_access
Licence (English):License LogoCreative Commons - CC BY 4.0 - Attribution 4.0 International