Safety, mortality, and hemodynamic impact of patients with MitraClip undergoing left ventricular assist device implantation

The interactions and hemodynamic impact of transcatheter percutaneous mitral valve repair (TMR) have not yet been investigated in patients undergoing left ventricular assist device (LVAD) implantation, but hemodynamic adverse effects are feared in the combination of TMR and LVAD for altered mitral valve flow. This study investigated the hemodynamic interplay in combination of TMR and LVAD in 119 patients, and propensity score match analysis revealed no difference in both perioperative mortality and 2-year follow-up survival (\(\it p\) = 0.84). Nonetheless, postoperatively mean pulmonary arterial pressure, pulmonary capillary wedge pressure, and cardiac index improved, and multivariable cox regression analysis at 2 years identified preoperative total bilirubin and temporary right ventricular mechanical circulatory support as independent risk factors for all-cause mortality but not TMR. Prior TMR has no impact on mortality or cardiovascular complications in patients with LVAD.

Metadaten
Author:	Henrik Fox ORCiD GND, Takayuki Gyoten ORCiD GND, Sebastian Rojas Hernandez ORCiD GND, Marcus-André Deutsch ORCiD GND, René Schramm ORCiD GND, Volker Rudolph ORCiD GND, Jan Gummert ORCiD GND, Michiel Morshuis ORCiD GND
URN:	urn:nbn:de:hbz:294-106447
DOI:	https://doi.org/10.1007/s12265-021-10178-w
Parent Title (English):	Journal of cardiovascular translational research
Publisher:	Springer
Place of publication:	New York
Document Type:	Article
Language:	English
Date of Publication (online):	2024/01/15
Date of first Publication:	2021/10/28
Publishing Institution:	Ruhr-Universität Bochum, Universitätsbibliothek
Tag:	CentriMag system; Heart failure; Heart transplantation; HeartMate 3; Left ventricular assist device; Left ventricular dysfunction; Mechanical circulatory support; MitraClip; Mortality; Pulmonary artery pressure; Pulmonary vascular resistance; Transpulmonary gradient
Volume:	15
First Page:	676
Last Page:	686
Note:	Dieser Beitrag ist auf Grund des DEAL-Springer-Vertrages frei zugänglich.
Institutes/Facilities:	Herz- und Diabeteszentrum NRW
	Herz- und Diabeteszentrum NRW, Klinik für Thorax- und Kardiovaskularchirurgie
	Herz- und Diabeteszentrum NRW, Zentrum für Herzinsuffizienz
Dewey Decimal Classification:	Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit
open_access (DINI-Set):	open_access
Licence (English):	Creative Commons - CC BY 4.0 - Attribution 4.0 International

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