Low-density lipoprotein receptor-related protein-1 (LRP1) in the glial lineage modulates neuronal excitability

  • The low-density lipoprotein related protein receptor 1 (LRP1), also known as CD91 or \(\alpha\)-Macroglobulin-receptor, is a transmembrane receptor that interacts with more than 40 known ligands. It plays an important biological role as receptor of morphogens, extracellular matrix molecules, cytokines, proteases, protease inhibitors and pathogens. In the CNS, it has primarily been studied as a receptor and clearance agent of pathogenic factors such as A\(\beta\)-peptide and, lately, Tau protein that is relevant for tissue homeostasis and protection against neurodegenerative processes. Recently, it was found that LRP1 expresses the Lewis-X (Lex) carbohydrate motif and is expressed in the neural stem cell compartment. The removal of \(\it Lrp1\) from the cortical radial glia compartment generates a strong phenotype with severe motor deficits, seizures and a reduced life span. The present review discusses approaches that have been taken to address the neurodevelopmental significance of LRP1 by creating novel, lineage-specific constitutive or conditional knockout mouse lines. Deficits in the stem cell compartment may be at the root of severe CNS pathologies.

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Author:Andreas FaissnerORCiDGND
Parent Title (English):Frontiers in network physiology
Publisher:Frontiers Media
Place of publication:Lausanne
Document Type:Article
Date of Publication (online):2024/01/12
Date of first Publication:2023/06/13
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Tag:Open Access Fonds
(GLAST) glutamate aspartate transporter; Emx1; NG2 (CSPG4) chondroitin sulfate proteoglycan; astrocyte; epilepsy; low-density lipoprotein receptor-related protein-1 (LRP1); radial glia; tissue plasminogen activator (tPA)
Issue:Article 1190240
First Page:1190240-01
Last Page:1190240-15
Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum.
Institutes/Facilities:Lehrstuhl für Zellmorphologie und Molekulare Neurobiologie
Dewey Decimal Classification:Naturwissenschaften und Mathematik / Biowissenschaften, Biologie, Biochemie
open_access (DINI-Set):open_access
faculties:Fakultät für Biologie und Biotechnologie
Licence (English):License LogoCreative Commons - CC BY 4.0 - Attribution 4.0 International