The safety and efficacy of ultrasound-accelerated catheter-directed thrombolysis in patients with intermediate–high-risk pulmonary embolism

  • Ultrasound-accelerated thrombolysis (USAT) is an advanced interventional therapy for patients with intermediate–high-risk pulmonary embolism (PE) who deteriorated on anticoagulation or for high-risk patients for whom systemic thrombolysis is contraindicated. The aim of this study is to investigate the safety and efficacy of this therapy with a focus on the improvement of vital signs and laboratory parameters. Seventy-nine patients with intermediate–high-risk PE were treated with USAT from August 2020 to November 2022. The therapy significantly decreased the mean RV/LV ratio from 1.2 \(\pm\) 0.22 to 0.9 \(\pm\) 0.2 (\(\it p\) < 0.001) as well as the mean PAPs from 48.6 \(\pm\) 11 to 30.1 \(\pm\) 9.0 mmHg (\(\it p\) < 0.001). The respiratory and heart rate decreased significantly (\(\it p\) < 0.001). Serum creatinine decreased significantly from 1.0 \(\pm\) 0.35 to 0.9 \(\pm\) 0.3 (\(\it p\) < 0.001). There were 12 access-associated complications, which could be treated conservatively. One patient had haemothorax after the therapy and had to be operated on. USAT is an effective therapy for patients with intermediate–high-risk PE, with favourable hemodynamic, clinical, and laboratory outcomes.

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Author:Hani Al-TerkiORCiDGND, Andreas MüggeORCiDGND, Michael GotzmannORCiDGND, Vedat TiyeriliGND, Friederike KleinGND, Marcus FranzORCiDGND, Sven Möbius-WinklerGND, Abdelrahman ElhakimORCiDGND
Parent Title (English):Journal of clinical medicine
Subtitle (English):Bo-NE-experience
Place of publication:Basel
Document Type:Article
Date of Publication (online):2024/01/11
Date of first Publication:2023/05/14
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Tag:Open Access Fonds
USAT; \(EKOS^{TM}\); actilyse; pulmonary embolism
Issue:10, Article 3459
First Page:3459-1
Last Page:3459-11
Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum.
Institutes/Facilities:St. Josef-Hospital Bochum, Klinik für Kardiologie, Abteilung für Rhythmologie
St. Josef-Hospital Bochum, Klinik für Kardiologie
Dewey Decimal Classification:Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit
open_access (DINI-Set):open_access
Licence (English):License LogoCreative Commons - CC BY 4.0 - Attribution 4.0 International