\(EKOS^{TM}\) in octogenarians

  • Background: Pulmonary embolism (PE) is a common cardiovascular disease. Elderly patients with acute PE have very high mortality rates. Data concerning the safety and effectiveness of ultrasound-accelerated thrombolysis (USAT) in this age group are lacking. Methods: Nineteen octogenarians with acute pulmonary embolism underwent USAT between August 2020 and February 2023 at two centres in Germany and were retrospectively analysed. The main efficacy measures were the right ventricle to left ventricle diameter (RV/LV) ratio, systolic right ventricle function, and invasive and echocardiographic measured systolic pulmonary artery pressure (sPAP). The main safety measures were in-hospital death and the bleeding rate according to the GUSTO bleeding score. Results: USAT was associated with an improved RV/LV ratio (0.36 \(\pm\) 0.29, \(\it p\) < 0.001), systolic right ventricle function (5.0 \(\pm\) 3.8, \(\it p\) < 0.001), and systolic pulmonary artery pressure (sPAP) at 24 h after therapy (24.2 \(\pm\) 11.2 mmHg and 19 \(\pm\) 13.4 mmHg, \(\it p\) < 0.001). No in-hospital deaths or bleeding complications occurred. Conclusions: USAT with \(EKOS^{TM}\) may be a safe and effective therapeutic option for octogenarians with acute pulmonary embolism.

Download full text files

Export metadata

Additional Services

Share in Twitter Search Google Scholar
Author:Hani Al-TerkiORCiDGND, Abdelrahman ElhakimORCiDGND, Andreas MüggeORCiDGND
Parent Title (English):Journal of clinical medicine
Subtitle (English):the safety and efficacy of ultrasound-accelerated catheter-directed thrombolysis in elderly patients with intermediate-high-risk pulmonary embolism
Place of publication:Basel
Document Type:Article
Date of Publication (online):2024/01/02
Date of first Publication:2023/04/04
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Tag:Open Access Fonds
USAT; \(EKOS^{TM}\); octogenarians; pulmonary embolism
Issue:7, Article 2712
First Page:2712-1
Last Page:2712-9
Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum.
Institutes/Facilities:St. Josef-Hospital Bochum, Klinik für Kardiologie, Abteilung für Rhythmologie
St. Josef-Hospital Bochum, Klinik für Kardiologie
Dewey Decimal Classification:Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit
open_access (DINI-Set):open_access
Licence (English):License LogoCreative Commons - CC BY 4.0 - Attribution 4.0 International