Bipolar chronobiology in men and mice

  • In patients with bipolar disorder, we do not only see a cycling of mood episodes, but also a shift in circadian rhythm. In the present overview, the circadian rhythm, the "internal clock", and their disruptions are briefly described. In addition, influences on circadian rhythms such as sleep, genetics, and environment are discussed. This description is conducted with a translational focus covering human patients as well as animal models. Concluding the current knowledge on chronobiology and bipolar disorder, implications for specificity and the course of bipolar disorder and treatment options are given at the end of this article. Taken together, circadian rhythm disruption and bipolar disorder are strongly correlated; the exact causation, however, is still unclear.

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Author:Nadja FreundORCiDGND, Ida Sibylle HaußleiterORCiDGND
Parent Title (English):Brain sciences
Subtitle (English):a narrative review
Place of publication:Basel
Document Type:Article
Date of Publication (online):2024/01/11
Date of first Publication:2023/04/29
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Tag:Open Access Fonds
circadian; sleep; translational
Issue:5, Article 738
First Page:738-1
Last Page:738-11
Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum.
Institutes/Facilities:LWL-Universitätsklinikum Bochum, Klinik für Psychiatrie, Psychotherapie und Präventivmedizin
Dewey Decimal Classification:Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit
open_access (DINI-Set):open_access
Licence (English):License LogoCreative Commons - CC BY 4.0 - Attribution 4.0 International