The antineoplastic effect of dimethyl fumarate on virus-negative Merkel cell carcinoma cell lines

  • Merkel cell carcinoma (MCC) is a rare, difficult-to-treat skin cancer once immunotherapy has failed. MCC is associated either with the clonal integration of the Merkel cell polyomavirus (MCPyV) or mutagenic UV-radiation. Fumaric acid esters, including dimethyl fumarate (DMF), have been shown to inhibit cell growth in cutaneous melanoma and lymphoma. We aimed to explore the effects of DMF on MCPyV-negative MCC cell lines. Three MCC cell lines (MCC13, MCC14.2, and MCC26) were treated with different doses of DMF. The cytotoxic effects and cell proliferation were assessed by the MTT cytotoxicity assay and BrdU proliferation assay at different time points. A significant reduction in cell viability and proliferation were demonstrated for all the cell lines used, with DMF proving to be effective.

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Author:Thilo GambichlerORCiDGND, Lyn G. BrüggestratGND, Marina SkryganGND, Christina ScheelORCiDGND, Laura SusokGND, Jürgen C. BeckerORCiDGND
Parent Title (English):Cancers
Subtitle (English):preliminary results
Place of publication:Basel
Document Type:Article
Date of Publication (online):2023/12/22
Date of first Publication:2023/01/16
Publishing Institution:Ruhr-Universität Bochum, Universitätsbibliothek
Tag:Open Access Fonds
dimethyl fumarate; fumaric acid esters; merkel cell carcinoma; monomethyl fumarate
Issue:2, Article 547
First Page:547-1
Last Page:547-11
Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum.
Institutes/Facilities:Katholisches Klinikum Bochum, Dermatologie, Venerologie und Allergologie
Dewey Decimal Classification:Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit
open_access (DINI-Set):open_access
Licence (English):License LogoCreative Commons - CC BY 4.0 - Attribution 4.0 International