Efficient Pd-catalyzed direct coupling of aryl chlorides with alkyllithium reagents
- Organolithium compounds are amongst the most important organometallic reagents and frequently used in difficult metallation reactions. However, their direct use in the formation of C−C bonds is less established. Although remarkable advances in the coupling of aryllithium compounds have been achieved, Csp\(^{2}\)−Csp3 coupling reactions are very limited. Herein, we report the first general protocol for the coupling or aryl chlorides with alkyllithium reagents. Palladium catalysts based on ylide-substituted phosphines (YPhos) were found to be excellently suited for this transformation giving high selectivities at room temperature with a variety of aryl chlorides without the need for an additional transmetallation reagent. This is demonstrated in gram-scale synthesis including building blocks for materials chemistry and pharmaceutical industry. Furthermore, the direct coupling of aryllithiums as well as Grignard reagents with aryl chlorides was also easily accomplished at room temperature.
| Author: | Thorsten ScherpfGND, Henning SteinertORCiDGND, Angela GroßjohannGND, Katharina DilchertGND, Jens TappenGND, Ilja RodsteinGND, Viktoria H. Däschlein-GessnerORCiDGND |
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| URN: | urn:nbn:de:hbz:294-99291 |
| DOI: | https://doi.org/10.1002/anie.202008866 |
| Parent Title (German): | Angewandte Chemie International Edition |
| Publisher: | Wiley-VCH |
| Place of publication: | Hoboken, New Jersey |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2023/05/30 |
| Date of first Publication: | 2020/07/29 |
| Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
| Tag: | catalysis; cross-coupling reactions; organolithium; phosphine ligands; ylides |
| Volume: | 59 |
| Issue: | 46 |
| First Page: | 20596 |
| Last Page: | 20603 |
| Note: | Dieser Beitrag ist auf Grund des DEAL-Wiley-Vertrages frei zugänglich. |
| Institutes/Facilities: | Lehrstuhl für Anorganische Chemie II |
| Dewey Decimal Classification: | Naturwissenschaften und Mathematik / Chemie, Kristallographie, Mineralogie |
| open_access (DINI-Set): | open_access |
| faculties: | Fakultät für Chemie und Biochemie |
| Licence (English): |  Creative Commons - CC BY-NC-ND 4.0 - Attribution-NonCommercial-NoDerivatives 4.0 International |
