Peripheral spondyloarthritis and psoriatic arthritis \(\textit {sine psoriase}\)
- Diagnosing peripheral spondyloarthritis (pSpA) remains a significant challenge due to the lack of specific disease biomarkers and the overlap with other SpA subtypes, mainly psoriatic arthritis (PsA), which represents a diagnostic challenge particularly in the absence of skin psoriasis (PsA \(\textit {sine psoriase}\)). This narrative review aimed to compare the epidemiology, genetic susceptibility, pathophysiology, classification criteria, disease phenotype and burden, and therapeutic guidelines between patients diagnosed with pSpA and those with PsA \(\textit {sine psoriase}\), to determine if the two entities should be considered jointly or distinctly. Globally, pSpA appears to be more inclusive compared with PsA \(\textit {sine psoriase}\). Areas of similarities include age of onset, number of joints involved and prevalence of axial involvement. However, patients with pSpA have a male gender predominance, a higher prevalence of HLA-B27, enthesitis and involvement of large joints of the lower limbs, whereas patients with PsA \(\textit {sine psoriase}\) have a higher prevalence HLA-Cw6, dactylitis and involvement of hand distal interphalangeal joints. Therefore, the difference between pSpA and PsA \(\textit {sine psoriase}\) goes beyond semantics. The few dissimilarities should drive scientific efforts to reach a better characterisation of pSpA as an individual disease. Accordingly, randomised clinical trials should target patients with well-defined pSpA to identify effective therapies in this population.
Author: | Nelly ZiadeORCiDGND, Michel Bou AbsiGND, Xenofon BaraliakosORCiDGND |
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URN: | urn:nbn:de:hbz:294-103562 |
DOI: | https://doi.org/10.1136/rmdopen-2022-002592 |
Parent Title (English): | RMD Open |
Subtitle (English): | are we dealing with semantics or clinically meaningful differences? |
Publisher: | BMJ Publishing Group |
Place of publication: | London, Vereinigtes Königreich |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2023/11/10 |
Date of first Publication: | 2022/11/04 |
Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
Tag: | Open Access Fonds |
Volume: | 8 |
Issue: | 2, Article e002592 |
First Page: | e002592-1 |
Last Page: | e002592-12 |
Note: | Article Processing Charge funded by the Deutsche Forschungsgemeinschaft (DFG) and the Open Access Publication Fund of Ruhr-Universität Bochum. |
Institutes/Facilities: | Rheumazentrum Ruhrgebiet |
Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
open_access (DINI-Set): | open_access |
Licence (English): | Creative Commons - CC BY-NC 4.0 - Attribution-NonCommercial 4.0 International |