Case-control study
- \(\textit {Streptococcus gallolyticus}\) subsp. \(\it gallolyticus\) was identified in humans and animals as commensal of the gut and can act as a causative agent of endocarditis and septicemia. A case-control study was performed to identify yet unknown risk factors for the transmission of this facultative pathogen. The prevalence in the gut of 99 healthy volunteers was determined using real-time polymerase chain reaction resulting in 62.5% \(\textit {S. gallolyticus}\) subsp. \(\it gallolyticus\) positive excrements. Subsequent cultivation offered three isolates and epidemiological analysis based on MLST revealed sequence type (ST) 3 and ST 7, previously detected from bovine and endocarditis patients. These results support the hypotheses of the zoonotic potential of this bacterium. Participant questionnaires were evaluated concerning personal characteristics, nutritional habits and animal contact. Specifically, closer contact between participants and animals influenced the colonization of the human gut significantly and was further affected if volunteers used excrement for the fertilization of plants.
Author: | Jessika DumkeGND, Tanja VollmerGND, Oke AkkermannGND, Cornelius KnabbeGND, Jens DreierGND |
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URN: | urn:nbn:de:hbz:294-73657 |
DOI: | https://doi.org/10.1371/journal.pone.0176515 |
Parent Title (English): | PLoS ONE |
Subtitle (English): | Determination of potential risk factors for the colonization of healthy volunteers with \(\textit {Streptococcus gallolyticus}\) subsp. \(\it gallolyticus\) |
Publisher: | Public Library of Science |
Place of publication: | San Francisco |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2020/07/22 |
Date of first Publication: | 2017/05/01 |
Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
Volume: | 12 |
Issue: | 5, Artikel e0176515 |
First Page: | e0176515-1 |
Last Page: | e0176515-12 |
Institutes/Facilities: | Herz- und Diabeteszentrum NRW, Institut für Laboratoriums- und Transfusionsmedizin |
open_access (DINI-Set): | open_access |
Licence (English): | Creative Commons - CC BY 4.0 - Attribution 4.0 International |