Synthesis and kinetic studies of some model peptides

The thesis is mainly concerned with synthesis, kinetic studies and conformational analysis of some model peptides. We have compared the UV-Vis absorption spectra, the \(\textit {trans-to-cis}\) photoisomerization and the \(\it {cis-to-trans}\) thermal isomerization of azobenzene peptides with those of precursor 4,4´-diaminoazobenzene, 4,4´-dicarboxylic acid azobenzene and parent azobenzene. The thermal decay is exponential and follows the first-order kinetics in all the cases we have considered. Whatever the substituent is, the rate is always faster than that of parent \(\it {cis}\)-azobenzene. Our experimental work shows that the energy of activation is different from substituent to substituent and even from solvent to solvent. The chain elongations of both the push-push and pull-pull azobenzenes by amide group with alanine residues cause the rate reduction in all cases. The rate reduction of amide derivatives from push-push azobenzene is more significant than that of amide derivatives from pull-pull azobenzene.

Metadaten
Author:	Khurshida Khayer GND
URN:	urn:nbn:de:hbz:294-15460
Referee:	Wolfram Sander ORCiD GND, Martin Feigel GND, Martina Havenith ORCiD GND
Document Type:	Doctoral Thesis
Language:	English
Date of Publication (online):	2006/02/28
Date of first Publication:	2006/02/28
Publishing Institution:	Ruhr-Universität Bochum, Universitätsbibliothek
Granting Institution:	Ruhr-Universität Bochum, Fakultät für Chemie und Biochemie
Date of final exam:	2006/01/31
Creating Corporation:	Fakultät für Chemie und Biochemie
GND-Keyword:	Peptide; Azobenzol; Konformation; Peptidsynthese; Photochemie
Institutes/Facilities:	Lehrstuhl für Organische Chemie II
Dewey Decimal Classification:	Naturwissenschaften und Mathematik / Chemie, Kristallographie, Mineralogie
faculties:	Fakultät für Chemie und Biochemie
Licence (German):	Keine Creative Commons Lizenz - es gelten der Veröffentlichungsvertrag und das deutsche Urheberrecht

RUB » Bibliotheksportal