Functions and mechanisms of Survival Promoting Peptide (SPP/ Y-P30)
Funktionen und Mechanismen von Survival Promoting Peptide (SPP / Y-P30)
- Survival Promoting Peptide/Y-P30 is produced by peripheral blood mononuclear cells of pregnant rats & humans. It is imported to the cortical neurons of early postnatal rat and fetal humans. Y-P30 promotes survival of thalamic neurons and neurite outgrowth in thalamic and cerebellar cultures. However other functions of Y-P30 during early development were not known, also the intracellular mechanisms remain to be elucidated. The main aim of this thesis was to investigate the roles of Y-P30 on some steps of development & to obtain knowledge of the intracellular signaling. We found that Y-P30 enhances migration of different cells without influencing their proliferation. Studies on neuronal differentiation revealed that Y-P30 neutralization enhances dendrite growth & Y-P30 enhances the axon growth. For later, Y-P30 signals via syndecan-3 to activate src & Erk signaling leading to actin modulation. The data suggests that Y-P30 plays important role during development & may be regeneration.
Author: | Suvarna Dash-WaghGND |
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URN: | urn:nbn:de:hbz:294-25050 |
Subtitle (English): | a maternally derived peptide in developing central nervous system |
Subtitle (German): | Rolle eines maternal sezernierten Peptids für die Entwicklung des zentralen Nervensystems |
Referee: | Petra WahleORCiDGND, Rolf HeumannORCiDGND |
Document Type: | Doctoral Thesis |
Language: | English |
Date of Publication (online): | 2009/04/06 |
Date of first Publication: | 2009/04/06 |
Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
Granting Institution: | Ruhr-Universität Bochum, Fakultät für Biologie und Biotechnologie |
Date of final exam: | 2008/12/12 |
Creating Corporation: | Fakultät für Biologie und Biotechnologie |
GND-Keyword: | Großhirnrinde; Entwicklung; Axon; Dendrit; Migration (Biologie) |
Institutes/Facilities: | Lehrstuhl für Allgemeine Zoologie und Neurobiologie, Arbeitsgruppe für Entwicklungsneurobiologie |
Dewey Decimal Classification: | Naturwissenschaften und Mathematik / Biowissenschaften, Biologie, Biochemie |
faculties: | Fakultät für Biologie und Biotechnologie |
Licence (German): | Keine Creative Commons Lizenz - es gelten der Veröffentlichungsvertrag und das deutsche Urheberrecht |