Addressing, amplifying and switching DNAzyme functions by electrochemically-triggered release of metal ions

  • The design of artificial cells, which mimic the functions of native cells, is an ongoing scientific goal. The development of stimuli-responsive chemical systems that stimulate cascaded catalytic transformations, trigger chemical networks, and control vectorial branched transformations and dose-controlled processes, are the minimum requirements for mimicking cell functions. We have studied the electrochemical programmed release of ions from electrodes, which trigger selective DNAzyme-driven chemical reactions, cascaded reactions that self-assemble catalytic DNAzyme polymers, and the ON–OFF switching and dose-controlled operation of catalytic reactions. The addressable and potential-controlled release of Pb2+ or Ag+ ions into an electrolyte that includes a mixture of nucleic acids, results in the metal ion-guided selection of nucleic acids yielding the formation of specific DNAzymes, which stimulate orthogonal reactions or activate DNAzyme cascades.

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Author:Lina Freage, Alexander Trifonov, Ran Tel-Vered, Eyal Golub, Fuan Wang, John S. McCaskillGND, Itamar Willner
Parent Title (English):Chemical science
Document Type:Article
Date of Publication (online):2015/04/08
Date of first Publication:2015/04/08
Tag:MICREAGENTS, Project ID: 318671
First Page:3544
Last Page:3549
MICREAGENTS, Project ID: 318671
Relation (DC):info:eu-repo/grantAgreement/EC/FP7/318671
Dewey Decimal Classification:Naturwissenschaften und Mathematik / Chemie, Kristallographie, Mineralogie
Licence (German):License LogoCreative Commons - CC BY-NC 3.0 - Namensnennung-Nicht kommerziell